Recent research conducted by researchers from the Catholic University of Sacred Heart, Rome, led by Giovambattista Pani, and working with a number imuwan of the Institute of Human Physiology. Their results are published in the Proceedings of the National Academy of Sciences USA (PNAS).
In the study, researchers tested the rats given low-calorie foods. Caloric restriction was a positive effect on the brain and can enable molecules called CREB1. These molecules have important roles related to age and brain function.
"Our hope is to find a way to activate CREB1, for example through the new drug. As such, we do not need a strict diet to keep the brain young," said Dr Pani.
Researchers say, in mice fed calorie restriction tended not fat and not get sick with diabetes. In fact, these mice also have cognitive and memory performance is much better.
This finding is in line with previous research showing that obesity can negatively affect the brain and cause premature aging of the brain that are vulnerable to diseases such as Alzheimer's and Parkinson's. In contrast, calorie restriction would make the young brain.
From this research, the researchers concluded that the activity of CREB1 could be dramatically increased by simply reducing caloric intake. Thus, it is important to limit one's intake of calories in the brain.
"This discovery has important implications for developing therapies in the future, especially in keeping the brain stay young and prevent degeneration and the aging brain. In addition, our study describes the correlation between metabolic diseases such as diabetes and obesity to cognitive decline," he concluded.
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