Wednesday, February 15, 2012

High cholesterol may trigger Alzheimer's

Alzheimer disease is one of the most common form of dementia was found. Alzheimer's risk usually increases with age. But a recent study showed that those who have high cholesterol levels at risk for Alzheimer's.
The findings, published in the journal Neurology suggests that high cholesterol levels may increase the risk of Alzheimer's disease by creating more plaque in the brain. 



However, this finding does not directly prove that high cholesterol can lead to Alzheimer's disease or a decrease in mean cholesterol level will decrease the risk of Alzheimer's. Researchers also found no association between high cholesterol with plaque tangles that clog the brains of people with Alzheimer's disease.
Kensuke Sasaki, expert neuropathology at Kyushu University, Japan, said the findings reinforce previous research linking insulin resistance to Alzheimer's disease. As is known, control cholesterol levels and insulin resistance, is the best prevention of cardiovascular disease risk, "which may also contribute to Alzheimer's disease prevention strategies," said Sasaki.
According to the Alzheimer's Association data, an estimated 5.4 million Americans have Alzheimer's disease, and this number is expected to grow to 16 million people in 2050. So far have not found a way to prevent or cure Alzheimer's.
The researchers have examined the brains of 147 volunteers (76 male and 71 female) Japanese city residents who live in 1988 and had undergone clinical examination. About a third of them have been diagnosed with dementia, although they showed no signs of it in 1988.
The result is found, compared with a group of people with low cholesterol levels, those with high cholesterol levels are more likely to be found in the brain protein known as plaques by 62 percent (low cholesterol) and 86 percent (high cholesterol).
Meanwhile, dr. Marc L. Gordon, head of neurology at Zucker Hillside Hospital, Glen Oaks, said the findings are very credible and interesting. This added to speculation that already exist, in which high cholesterol levels in middle age, especially the so-called "bad" cholesterol, can increase the risk of Alzheimer's later in the day, said Gordon, who is also a matter of Alzheimer's researcher at the Feinstein Institute for Medical Research.
According to Gordon, it is unknown exactly how cholesterol can make the plaque, although cholesterol is found in plaque. It is possible that high cholesterol can trigger other processes that cause Alzheimer's or something else.
Gordon noted, high cholesterol and obesity seemed to decline in people who have dementia, although it may have something related to changes in their eating habits.

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