People
with diabetes are two times higher risk of having a heart attack, it is
already known although the exact cause is still unclear to scientists. But
a study at the University of Iowa (UI), the United States, successfully
demonstrated two diseases related due to disruption of the enzyme on
the heart by diabetes.
"Many
studies have shown that patients with diabetes, in particular, is very
risky died due to myocardial infarction (heart attack). Our
study shows new evidence that the oxidized enzyme CaMKII plays an
important role in the cause of death, "said Mark Anderson, author of the
report UI professor of research in the Journal of Clinical
Investigation quoted by Xinhua (16/02/2013).
Eight percent of the U.S. population have diabetes. And deaths from heart attacks experienced by many diabetics.
Diabetes is known to increase oxidative stress leading to cell damage. In
2008, Anderson's research laboratory in the UI indicates that the
enzyme CaMKII (calcium / calmodulin - dependent protein kinase II)
activated by oxidation.
Recent
research this time linking oxidative stress associated with diabetes
with increased risk of death from heart attack through activation of
CaMKII enzyme-based oxidation.
Diabetic rats in the laboratory showed they died due to heart rhythm disturbances. This prompted scientists to further investigate cardiac rhythm regulators cells.
In diabetic mice that die from a heart attack looks cells control the heart rhythm were dying teroksidasinya CaKMII enzyme. When
researchers tried to block the process of oxidation enzyme, the risk of
cell damage decreased heart rhythm regulator so that the risk of death
from heart attack is reduced.
The
results of this research into new approaches in the prevention of heart
attacks, namely by reducing the oxidation of cardiac enzymes in
patients with diabetes.
No comments:
Post a Comment