Cancer is a disease that causes major morbidity and death in the world. Development of cancer drugs continues to be done, including utilizing medicinal plants as agents kemoprevensi or anti-cancer agent.
One of them is Yuni Widiyastuti, a doctoral candidate who studies further one of the Family of Laureaceae, which is avocado. Family Laureaceae is one of the families most studied its potential as an anti-cancer agent.
Utilizing avocado seeds, Yuni explore the potential of this natural ingredients to be used as an anti-cancer drug. The result, known avocado seeds are natural ingredients that can be used to overcome the development of breast cancer cells MCF-7.
He said, avocado seeds contain compounds alkaloids, flavonoids, saponins, terpenoids, tannins and essential oils. According Yuni, the compounds that belong to the class of compounds that are anti-cancer.
"The chlorophomic extract of avocado seeds is cytotoxic, which can inhibit the growth of breast cancer cells MCF07," Yuni said during an open examination of doctoral program at Graduate School of Gadjah Mada University, Friday (28/7).
Researchers from Central Research and Development of Medicinal Plants and Traditional Medicine of Central Java added that the active compound of avocado seeds proved able to induce the death of MCF-7 cells, by making DNA damage. In addition, the number of cells experiencing death increased after treatment on the nysis flow cytometry.
"Avocado seed compounds were able to increase the expression of p53, pRb, caspase 3, and decrease expression of the Bel-2 atiaapoctosis gene, but increase Bax pro-apoptoses gene expression," he said.