Wednesday, July 11, 2018

Scientists Now Categorize Diabetes So Five Types

A recent study published in The Lancet Diabetes and Endocrinology. The study, led by Professor Leif Groop of the Diabetes Center at Sweden's Lund University and the Finnish Molecular Medical Institute, proves that people with diabetes get better benefits and better treatment if the disease is categorized into five types, not just two types that are known to the public.

In the United States, about 30.3 million people are living with diabetes. This does not include gestational diabetes, which is diabetes that develops during pregnancy. In general, diabetes is only grouped into two types, one and two.

In type-1 diabetes, pancreatic beta cells that produce insulin, or hormones that regulate blood sugar levels are attacked and destroyed by the immune system. Type 2 diabetes is the most common form, accounting for 90-95 percent of all cases. This occurs when the body's cells stop responding to insulin or beta cells and can not produce enough hormone.

Researchers analyzed data from four cohort studies. The study included 14,775 adults in Switzerland and Finland who were all diagnosed with diabetes. Scientists looked at body mass index (BMI), age at diagnosis of diabetes, hemoglobin A1C (HbA1C), blood sugar control, beta cell function, insulin resistance, and the presence of diabetes-related autoantibodies. Researchers also conducted genetic analysis of the participants, then compared the progress of the disease, complications, and treatment they had undergone.

Quoted from Medical News Today, Wednesday (11/7), this study revealed five different forms of diabetes. Three were severe and two were light.

Diabetes cluster-1

Severe autoimmune diabetes is now known as type-1 diabetes. The sign is lack of insulance, the presence of autoantibodies. It was identified as attacking 6-15 percent of the study subjects.

Diabetes cluster-2

Diabetes lacks severe insulin. The signs are younger age, insulin deficiency, poor metabolic control, but no autoantibodies. It was identified in 9-20 percent of the study subjects.

Diabetes cluster-3

Diabetes is a severe insulin resistance. The sign is a very severe insulin resistance, the risk of kidney disease is higher. It was identified as attacking 11-17 percent of the study subjects.

Diabetes Cluster-4

Diabetes is associated with mild obesity, and most commonly affects individuals with obesity. This affects 18-23 percent of subjects.

Diebetes cluster-5

Age-related diabetes, most common in older people. This is the most common form that affects 39-47 percent of research subjects.

Professor Groop and his colleagues suggest that diabetes should be categorized into five different types. This is a major step forward and existing treatment guidelines.

"This study moves us toward a more clinically beneficial diagnosis, an important step toward precision treatment in diabetes," says Groop.

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