Hexane extracts of black cumin (Nigella sativa Lor) was developed as a potential immunomodulator in patients with immunodeficiencies such as HIV-AIDS infected patients has decreased the number of CD4 cells, said Akrom Kes, lecturer at the Faculty of Pharmacy, University Ahmad Dahlan in Yogyakarta.
"Hexane extract of black cumin seeds (EHBJH) can be developed as a chemopreventive agent antikarsinogenesis through cytoprotective antioxidant and immunomodulatory mechanisms," he said in an open doctoral examination in the Faculty of Medicine, University of Gadjah Mada (UGM) in Yogyakarta, on Monday (04/02/2013).
According to him, the effect EHBJH can improve lymphocyte CD4, CD8, IFNgamma levels, and hematoprotektor. The success of black cumin seeds to increase the number of CD4 and CD8 cells as well as the impact on CD4CD25Treg cell population gives hope to patients with HIV-AIDS antiretroviral therapy (ARV) as adjuvant therapy.
"Although the new scale laboratory research through the provision of hexane extracts of black cumin seeds in mice, known timokuinon have chemopreventive effects in rats even antikarsinogenesis can reduce 81-97 percent mortality rate, inhibits liver and kidney damage as well as increase the number of leukocytes and hemoglobin," he said.
He said, cumin seed hexane extract was also able to reduce the incidence of nodule formation 45-50 percent and 70-90 percent lower rat mammary adenocarcinoma formation induced dimetilbenz (a) antracene.
In addition, activity and immunomodulatory mechanisms antihematoksik hexane extracts of black cumin seeds is known to increase the number of peripheral blood lymphocytes, increases the number of lymphocytes CD4Th, CD8 and CD4CD25treg, increase spleen weight and the number of lymphocytes and lymphocyte activity in secreting IFNgamma.
He said that black cumin seed has been empirically used as a herbal medicine for the treatment of a variety of disorders that can treat them as immunomodulatory, antiviral, antidiabetic mellitus, cancer, antiasma, and antiepileptics.
"The content timokuinon, nigelon, and unsaturated fatty acids in the seeds of the black cumin is thought to be the content of the antioxidative, chemopreventive, and immunomodulators," said Akrom.
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